Transient loss of high-level mupirocin resistance in Staphylococcus aureus due to MupA polymorphism.
نویسندگان
چکیده
Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10(-6)), indicating the transient nature of MupA polymorphism.
منابع مشابه
Association of high-level mupirocin resistance and multidrug-resistant methicillin-resistant Staphylococcus aureus at an academic center in the midwestern United States.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 6 شماره
صفحات -
تاریخ انتشار 2007